MersV1, Main, Exploration, bibRecord, 004D63

Studies on binding of toromycin, an antitumor antibiotic, to DNA

Identifieur interne : 004D63 ( Main/Exploration ); précédent : 004D62; suivant : 004D64

Studies on binding of toromycin, an antitumor antibiotic, to DNA

Auteurs : Kazuo Shishido [Japon] ; Ken-Ichi Joho [Japon] ; Masakazu Uramoto [Japon] ; Kiyoshi Isono [Japon] ; Tikam Jain [États-Unis]

Source :

Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1986.

RBID : ISTEX:F49733B5597015630C5E0430A1D6D30B47203AE6

English descriptors

Teeft :
- Academic press, Agarose, Antibiotic, Capital letters, Chem, Copolymer, Electrophoretic, Electrophoretic patterns, Gilvocarcin, Helix, Limited condition, Linear pns1, Nuclease, Nucleic acids, Plasmid, Pns1, Riken institute, Supercoiled, Supercoiled forms, Tokyo institute, Toromycin.

Abstract

Abstract: Toromycin, an antitumor, bactericidal and antiviral compound, was found to bind to DNA in such a way as to interfere with the dissociation of double helix at an elevated temperature. The antibiotic did not introduce strand scission into DNA. Single-strand-specific nuclease S1-susceptibility of negatively supercoiled DNA was not influenced by its binding. The antibiotic was shown to bind to both of the alternating purine-pyrimidine copolymers, poly(dG-dC):poly(dG-dC) and poly(dA-dT):poly(dA-dT). The unique C-glycoside molecule of toromycin interacted with single-stranded DNA, but was found to have no affinity for RNA.

Url:

https://api.istex.fr/ark:/67375/6H6-DXP0B204-2/fulltext.pdf

DOI: 10.1016/0006-291X(86)90415-8

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Toromycin, an antitumor, bactericidal and antiviral compound, was found to bind to DNA in such a way as to interfere with the dissociation of double helix at an elevated temperature. The antibiotic did not introduce strand scission into DNA. Single-strand-specific nuclease S1-susceptibility of negatively supercoiled DNA was not influenced by its binding. The antibiotic was shown to bind to both of the alternating purine-pyrimidine copolymers, poly(dG-dC):poly(dG-dC) and poly(dA-dT):poly(dA-dT). The unique C-glycoside molecule of toromycin interacted with single-stranded DNA, but was found to have no affinity for RNA.</div>
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Studies on binding of toromycin, an antitumor antibiotic, to DNA

Studies on binding of toromycin, an antitumor antibiotic, to DNA

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri